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目的对3例重症克山病患者同种原位心脏移植术后进行监测,探讨心脏移植术后急性排异反应的监测指标。方法监测指标:临床症状;12导联心电图;超声心动图;单光子计算机体层扫描;外周血T淋巴细胞检查;心内膜心肌活检;X线影像。结果行EMB19次,发现1b级和2级各1次,3a级2次。3a级时UCG发现心包积液有增加趋势,其余指标未见明显改变。结论心内膜心肌活检是诊断急性排异反应敏感可靠的指标,其它一些常用的指标不敏感且缺乏特异性,但可做为辅助指标。
Objective To monitor the status of acute rejection in three patients with severe Keshan disease after cardiac transplantation. Methods Monitoring indicators: clinical symptoms; 12-lead electrocardiogram; echocardiography; single photon computed tomography; peripheral blood T lymphocyte examination; endomyocardial biopsy; X-ray images. The results of EMB19 line, found that the first and second level of 1, 3, 2 times. 3a grade UCG found pericardial effusion has an increasing trend, the remaining indicators no significant change. Conclusion Endomyocardial biopsy is a sensitive and reliable indicator for the diagnosis of acute rejection. Some other commonly used indexes are not sensitive and specific, but can be used as auxiliary indicators.