目的 :探讨中央角膜厚度和眼压对高度近视准分子激光原位角膜磨镶术 (excimerlaser in- situ keratomileusis,L ASIK)疗效的影响。方法 :采用 L ASIK对 96例 16 6眼高度近视患者进行治疗。根据术前中央角膜厚度 (corneal thickness,CT)与术前眼压(intraocular pressure,IOP)之比值进行分组。分析术后裸眼视力与 CT/ IOP之间的关系。结果 :术后裸眼视力 0 .1～ 1.5 ,平均1.0 3± 0 .34,3组间差异有显著性 (P<0 .0 1)。多元回归和相关分析显示术前中央角膜厚度和眼压可影响术后裸眼视力 :角膜较厚、眼压较低 ,即 CT/ IOP值大 ,术后裸眼视力较好。结论 :L ASIK治疗高度近视是一种安全、有效的方法 ,但欲取得较好疗效 ,应考虑不同因素如术前中央角膜厚度和眼压等可能造成的影响 Objective: To investigate the effects of central corneal thickness and intraocular pressure (IOP) on the efficacy of high myopia laser in situ keratomileusis (LASIK). Methods: LASIK was used to treat 96 patients with high myopia of 16 6 eyes. The preoperative central corneal thickness (corneal thickness, corneal thickness (CT) and preoperative intraocular pressure (IOP) ratio grouping. The relationship between postoperative uncorrected visual acuity and CT / IOP was analyzed. Results: The uncorrected visual acuity was 0 .1 ~ 1.5, with an average of 1.03 ± 0.34, the difference between the 3 groups was significant (P <0. 01). Multivariate regression and correlation analysis showed that preoperative central corneal thickness and intraocular pressure can affect postoperative uncorrected visual acuity: thick cornea, low intraocular pressure, that CT / IOP value is large, postoperative visual acuity better. CONCLUSION: L ASIK is a safe and effective method for the treatment of high myopia. However, to obtain better therapeutic effect, various factors such as preoperative central corneal thickness and intraocular pressure may be considered