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目的 评价MA方案治疗老年急性髓细胞白血病 (AML)及观察老年AML治疗中应用G CSF的临床效果。方法 MA方案治疗老年AML36例 ,2 1例化疗中联合应用G CSF ,其余 1 5例未用G CSF作为对照。结果 ①MA方案治疗 36例老年AMLCR率 41 7% ,总有效率 75 0 %。②化疗中联合应用G CSF可缩短外周血白细胞减少和粒细胞缺乏的天数 ,化疗后白细胞恢复及应用抗生素的天数 ,其诱导相关死亡率明显低于未应用G CSF组。结论 MA方案可作为老年AML的一种较好的治疗方案。老年AML治疗联合应用G CSF可降低化疗药物骨髓抑制的毒副作用
Objective To evaluate the clinical efficacy of MA regimen in the treatment of senile acute myeloid leukemia (AML) and to observe the application of G CSF in elderly AML patients. Methods The MA regimen was used to treat 36 cases of elderly AML, 21 cases of chemotherapy combined with G CSF, and the remaining 15 cases without G CSF as a control. Results ① The AM regimen of 36 elderly patients treated with MA regimen was 41.7%, with a total effective rate of 75.0%. ② The combination of G CSF in chemotherapy can shorten the number of leukopenia and agranulocytosis, the recovery of leukocytes after chemotherapy, and the number of antibiotics days, the induced mortality is significantly lower than that of non-applied G CSF. Conclusion MA regimen can be used as a good treatment for elderly AML. AML treatment combined with G CSF can reduce the side effects of chemotherapy drugs in bone marrow suppression