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目的 :探讨黄芪与维生素 E对肢体缺血再灌注损伤有无保护作用 ,为指导临床用药提供理论依据。方法 :复制家兔缺血再灌注损伤模型 ,采用生化分析方法测定血清天冬氨酸氨基转移酶 ( AST)、肌酸激酶 ( CK)、丙二醛 ( MDA)、超氧化物歧化酶 ( SOD)的含量。结果 :黄芪与维生素 E治疗组 AST、CK、MDA水平较缺血再灌注组显著下降 ( P<0 .0 5 ) ,SOD显著升高 ( P<0 .0 5 )。结论 :黄芪与维生素 E对肢体缺血再灌注损伤具有明显的保护作用
Objective: To investigate the protective effects of astragalus root and vitamin E on limb ischemia-reperfusion injury and provide a theoretical basis for guiding the clinical medication. Methods: The model of ischemia-reperfusion injury in rabbits was duplicated. Serum levels of aspartate aminotransferase (AST), creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase ) Content. Results: The levels of AST, CK and MDA in astragalus membranaceus and vitamin E treatment group were significantly lower than those in ischemia-reperfusion group (P <0.05), and SOD was significantly increased (P <0.05). Conclusion: Astragalus membranaceus and vitamin E have a significant protective effect on limb ischemia-reperfusion injury