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目的 :检测老年肺癌患者血清和组织中一氧化氮 (NO)水平并探讨其临床意义。方法 :采用化学比色法测定 3 0例老年肺癌患者血清和组织中的NO浓度。结果 :老年肺癌患者的血清NO浓度显著高于正常对照组 (P <0 .0 1) ,鳞癌组血清NO浓度显著低于腺癌组 (P <0 .0 1) ;而组织中NO浓度显著低于正常对照组 (P <0 .0 1)。结论 :血清和组织中NO浓度变化可能与老年肺癌的发生、发展有关 ,对老年肺癌患者的病情变化判断和预后分析具有一定的临床意义
Objective: To detect the levels of nitric oxide (NO) in the serum and tissues of elderly patients with lung cancer and to explore its clinical significance. Methods: The concentrations of NO in serum and tissues of 30 elderly patients with lung cancer were determined by chemical colorimetry. Results: Serum NO concentration in elderly patients with lung cancer was significantly higher than that in normal controls (P <0.01). Serum NO levels in squamous cell carcinoma were significantly lower than those in adenocarcinoma (P <0.01) Significantly lower than the normal control group (P <0.01). CONCLUSION: The changes of NO in serum and tissue may be related to the occurrence and development of lung cancer in elderly patients. It is of clinical significance for the judgment and prognosis analysis of elderly patients with lung cancer