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有关α_1-m(α_1-微球蛋白)浓度与与肾脏损伤的关系已确定,但其与脑梗塞疾病的关系报道不多。本文检测了41例脑梗塞患者尿α_1-m的含量,以探讨了α_1-m在脑梗塞发病中的意义。 对象和方法 一、对象: (一)正常对照组:30例(男性25例,女性5例),年龄37～53岁,经体检均无心、肺、肾、肝等疾病。 (二)高血压病组:35例(男性28例,女性7例)年龄45～72岁,高血压病诊断标准符合WHO 1978年所拟定的标准。 (三)高血压并发脑梗塞组:41例(男性35例,女性6例),诊断依据依靠临床表现加CT证实。 二、方法: (三)尿α_1-m含量测定采用RIA法,试剂盒由小国原子能研究院同位素所提供,按说明书操作。仪器为西安二六二厂生产的FJ-2008Pγ-放射免疫计数器。
The relationship between α_1-m (α_1-microglobulin) concentration and renal damage has been established, but its relationship with cerebral infarction has not been reported yet. This article examines the content of urinary α_1-m in 41 patients with cerebral infarction to explore the significance of α_1-m in the pathogenesis of cerebral infarction. Subjects and Methods 1. Subjects: (1) Normal control group: 30 cases (25 males and 5 females), aged 37-53 years. None of the patients had heart, lung, kidney or liver disease after physical examination. (B) Hypertension group: 35 cases (28 males and 7 females) aged 45 to 72 years, the diagnostic criteria for hypertension in line with WHO in 1978 the proposed standard. (C) hypertension complicated by cerebral infarction group: 41 cases (35 males and 6 females), diagnosis based on clinical manifestations and CT confirmed. Second, the method: (three) urinary α_1-m content determination using RIA method, the kit provided by the State Nuclear Energy Research Institute isotopes, according to instructions. The instrument is FJ-2008Pγ-radioimmuno-counter manufactured by No.226 Plant in Xi’an.