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The central and peripheral neuroimmunomodulating effects of morphine were studied in our laboratory through the following aspects:(1) By giving different doses of morphine and its addiction on mouse and determining T-,B-lymphocyte proliferation and cytokine production; (2) The direct effects of serial concentrations of morphine on the responses of immune competent cells and cytokine production in vitro; (3) By using of microinjection of morphine into rat periaqueductal gray (PAG), the possible central regulating actions on immune responses of morphine were observed. (1) ip Morphine more than 5 mg·kg~(-1). d~(-1) for 7 d caused addiction in mice while only higher doses of morphine (40, 100
The central and peripheral neuroimmunomodulating effects of morphine were studied in our laboratory through the following aspects: (1) By giving different doses of morphine and its addiction on mouse and determining T-, B-lymphocyte proliferation and cytokine production; (2) The direct effects of serial concentrations of morphine on the responses of immune competent cells and cytokine production in vitro; (3) By using of microinjection of morphine into rat periaqueductal gray (PAG), the possible central regulating actions on immune responses of morphine were observed. ( 1) ip Morphine more than 5 mg · kg -1 (d -1) for 7 d caused addiction in mice while only higher doses of morphine (40, 100