抗瘤Ｉ号（ＡＴ－Ｉ）是临床抗肿瘤及辅助肿瘤治疗有效的中药胶囊剂，具有肯定的抑瘤效应及调节小鼠脾细胞ＩＬ－２，ＩＬ－６产生和ＮＫ细胞活性的作用，为了探讨其辅助肿瘤治疗的机理，观察了ＡＴ－Ｉ对正常、免疫受抑制和荷瘤小鼠脾淋巴细胞增殖和外周血ＷＢＣ数的影响，结果提示：ＡＴ－Ｉ低剂量能促进脾细胞增殖，大剂量反呈现抑制效应；同时，ＡＴ－Ｉ还能纠正环磷酰胺减少外周血ＷＢＣ数的不良反应． Anti-tumor I (AT-I) is an effective anti-tumor and adjuvant tumor treatment of traditional Chinese medicine capsules, with certain anti-tumor effect and regulation of mouse spleen cells IL-2, IL-6 production and NK cell activity, In order to explore its mechanism of adjuvant tumor therapy, the effect of AT-I on normal, immunosuppressed and tumor-bearing mice splenic lymphocyte proliferation and peripheral blood WBC count was observed. The results suggest that low dose of AT-I can promote the proliferation of spleen cells , High-dose anti-inhibition effect; the same time, AT-I can correct cyclophosphamide to reduce peripheral blood WBC adverse reactions.