明日叶(Angelica keiskei),又称明日草、八丈草,属于伞形科当归属,是一种耐寒的多年生草本植物,原产于日本的太平洋沿岸,主要应用于传统医药和食品[1]。近年来发现明日叶中富含具有生物活性的查尔酮、总黄酮和香豆素类化合物,能诱导癌细胞凋亡、抗氧化、抗血栓、抗炎和防糖尿病[2-5]。目前,国内外对于明日叶功效的研究较多,而对于其使用安全性评价 Angelica keiskei, also known as tomorrow’s grass, Hatsume, belonging to the genus Umbelliferae, is a hardy perennial herb native to Japan’s Pacific coast and used mainly in traditional medicine and foodstuffs. In recent years, it has been found that tomorrow’s leaves are rich in bioactive chalcones, flavonoids and coumarins, which can induce cancer cell apoptosis, anti-oxidation, anti-thrombosis, anti-inflammatory and anti-diabetic [2-5]. At present, there are more studies on the efficacy of tomorrow leaves at home and abroad, but for the evaluation of its use safety