论文部分内容阅读
中国钩吻中的主要生物碱—钩吻素-子(koumine)经用化学与谱学方法测定其结构和相对构型如2.钩吻素-子中醚氧的位置系用还原裂解法将2转化为双氢钩吻醇(4)而决定.碱性氮原子N(b)与乙烯基的位置关系通过将N(a)—乙酰双氢钩吻素-子(5)氧化脱羧为胺6而推定.异双氢钩吻素-子(7)经氧化为8和9,从而得到了N(b)右侧的结构信息,然后通过-系列的~1HNMR去偶试验,得出钩吻素-子的碳骨架.2的相对构型系通过~1HNMR分析而判断.钩吻素-子的立体结构已由两个独立的X射线衍射工作加以肯定,其绝对构型如2所示.文中给出了详细的核磁共振数据和质谱数据,并解析了几种可能的质谱碎片化途径.
The main alkaloids in Chinese kiss koumine - koumine by chemical and spectroscopic methods to determine its structure and relative configuration, such as 2. 2 into Dihydrosalginol (4) The positional relationship between the basic nitrogen atom N (b) and the vinyl group is determined by oxidative decarboxylation of the N (a) -acetylazagin-sub (5) (7) was oxidized to 8 and 9, and the structure information of the right side of N (b) was obtained, and then - series of ~ 1H NMR decoupling tests were conducted to find that the kiss The relative configuration of the carbon skeleton of the proton-subfamily.2 was judged by ~ 1H NMR analysis. The stereostructure of the glucagon-progeny has been affirmed by two independent X-ray diffraction workings, the absolute configuration of which is shown in Fig. The detailed NMR and MS data are given and several possible ways of MS fragmentation are analyzed.