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目的从肝肺相干角度出发,观察平肝清肺颗粒加减治疗小儿咳嗽变异性哮喘(CVA)的临床疗效及对肺功能、外周血EOS、血清总Ig E的影响。方法将80例小儿CVA患者按随机数字表法分为治疗组和对照组各40例。治疗组服用平肝清肺颗粒加减,对照组口服博利康尼片和孟鲁司特片。疗程14天。记录两组治疗前后患儿的临床综合改善率、日间及夜间症状评分、咳嗽缓解及消失时间、肺功能、外周血EOS计数、血清总Ig E水平。结果治疗组患儿总有效率为92.5%,优于对照组(P<0.05);治疗组患儿症状积分改善优于对照组(P<0.05);治疗组患儿咳嗽缓解及消失时间优于对照组(P<0.05);治疗组肺通气功能治疗后比较优于对照组(P<0.05);治疗组治疗后外周血EOS改善优于对照组(P<0.05);治疗组治疗后血清总Ig E水平的改善优于对照组。结论平肝清肺颗粒加减对小儿CVA有显著的临床疗效,可有效改善肺通气功能,降低患儿外周血EOS及血清总Ig E水平。
Objective To observe the clinical effects of Pinggan Qingfei Granule in treating children with cough variant asthma (CVA) and its effects on pulmonary function, peripheral blood EOS and total serum IgE from the perspective of hepatopulmonary coherence. Methods Eighty children with CVA were randomly divided into treatment group and control group according to random number table method. The treatment group taking Pinggan Qingfei granules addition and subtraction, the control group oral carbonic acid tablets and montelukast tablets. Treatment for 14 days. The clinical comprehensive improvement rate, daytime and nighttime symptom score, cough relief and disappearance time, pulmonary function, peripheral blood EOS count and total serum IgE level were recorded in both groups before and after treatment. Results The total effective rate of the treatment group was 92.5%, which was better than that of the control group (P <0.05). The symptom score of the treatment group was better than that of the control group (P <0.05). The treatment group had better cough relief and disappearance time (P <0.05). After treatment of pulmonary ventilation, the treatment group was superior to the control group (P <0.05). The improvement of EOS in the peripheral blood of the treatment group was better than that of the control group (P <0.05) The improvement of Ig E level was better than the control group. Conclusion Pinggan Qingfei granule addition and subtraction has a significant clinical effect on pediatric CVA, which can effectively improve pulmonary ventilation and reduce the level of EOS and serum IgE in children.