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目的探讨血清C肽联合糖化血红蛋白检测糖尿病的临床诊断价值。方法选取40例糖尿病患者作为观察组,另选40例进行体检的健康者作为对照组,对两组研究对象血清C肽联合糖化血红蛋白进行检测,对比分析两组研究对象的糖化血红蛋白、空腹血糖值、餐后2 h血糖值、血清C肽水平指标。结果观察组患者的糖化血红蛋白、空腹血糖值、餐后2 h血糖值及血清C肽水平指标分别为(9.43±2.30)%、(8.94±2.40)mmol/L、(13.17±2.08)mmol/L、(0.91±0.13)μg/L;对照组的糖化血红蛋白、空腹血糖值、餐后2 h血糖值及血清C肽水平指标分别为(5.38±0.71)%、(4.73±1.09)mmol/L、(4.94±1.61)mmol/L、(1.63±0.24)μg/L;观察组患者的血清C肽水平低于对照组,差异有统计学意义(P<0.05);观察组患者的血清糖化血红蛋白、空腹血糖值、餐后2 h血糖值明显高于对照组,差异有统计学意义(P<0.05)。结论血清C肽和糖化血红蛋白联合应用检测,可有效反映糖尿病患者的病情程度及血糖控制水平,对于诊断糖尿病有非常重要的意义,值得临床广泛推广应用。
Objective To investigate the clinical value of serum C-peptide combined with glycosylated hemoglobin in the diagnosis of diabetes mellitus. Methods 40 cases of diabetic patients were selected as observation group and 40 healthy subjects were selected as control group. Serum C-peptide combined with HbA1c and HbA1c were detected in two groups. The levels of HbA1c, fasting blood glucose , 2 h postprandial blood glucose, serum C-peptide level indicators. Results The indexes of HbA1c, fasting blood glucose, postprandial 2h blood glucose and serum C-peptide in the observation group were (9.43 ± 2.30)%, (8.94 ± 2.40) mmol / L and (13.17 ± 2.08) mmol / L , (0.91 ± 0.13) μg / L respectively. The indexes of HbA1c, fasting blood glucose, postprandial 2h blood glucose and serum C-peptide in the control group were (5.38 ± 0.71)% and (4.73 ± 1.09) mmol / (4.94 ± 1.61) mmol / L and (1.63 ± 0.24) μg / L, respectively. The level of serum C-peptide in the observation group was lower than that in the control group (P 0. 05). Serum glycosylated hemoglobin, The fasting blood glucose level and postprandial blood glucose level at 2 hours were significantly higher than those in the control group (P <0.05). Conclusions The combination of serum C-peptide and glycosylated hemoglobin can effectively reflect the severity of disease and the level of blood sugar control in patients with diabetes. It is very important for the diagnosis of diabetes mellitus, which is worthy of wide application in clinic.