论文部分内容阅读
目的 分析显微手术辅以放疗、化疗对小儿髓母细胞瘤治疗效果及其预后的影响。方法 将髓母细胞瘤患儿分为二组， 手术全切除组和手术未全切除组。前者术后只接受全神经轴放射治疗， 后者术后辅以放疗和化疗， 观察二组治疗效果和预后的差异。结果 手术全切除组术后肿瘤复发率２９ ．３ ％ ，１、２ 、５ 年生存率分别为１００ ％ 、９４．１ ％ 、８２．４％ ； 手术未全切除组术后肿瘤复发率８５．７％ ，１ 、２、５ 年的生存率分别为７１．４ ％ 、４２．９％ 、２８ ．６％ 。两组术后复发率和生存率均存在显著差异（ Ｐ＜０ ．０１） 。结论 显微外科手术能否行肿瘤全切除是影响小儿髓母细胞瘤治疗效果和预后的决定性因素， 术后放射治疗有利于防止肿瘤复发， 化疗对于未能行手术全切除的小儿髓母细胞瘤的治疗可能具有广阔的前景。
Objective To analyze the effect of microsurgery combined with radiotherapy and chemotherapy on pediatric medulloblastoma and its prognosis. Methods The patients with medulloblastoma were divided into two groups, the total resection group and the group not undergone surgery. The former received only the whole axis after radiotherapy, the latter supplemented with radiotherapy and chemotherapy, the two groups observed the difference between the treatment effect and prognosis. Results The rate of tumor recurrence in the total resection group was 29. The survival rates of 3%, 1, 2 and 5 years were 100%, 94.1% and 82.4% respectively. The tumor recurrence rate was 85.7% Respectively 71.4%, 42.9%, 28. 6%. The recurrence rate and survival rate of both groups were significantly different (P <0.01). Conclusion Microsurgery can perform tumor resection is a decisive factor affecting the therapeutic effect and prognosis of pediatric medulloblastoma. Postoperative radiotherapy is conducive to the prevention of tumor recurrence. Chemotherapy is not effective in the treatment of pediatric medulloblastoma The treatment may have a bright future.