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目的:探讨间接气道激发试验、运动负荷试验对判定哮喘药物疗效的意义.方法:慢阻肺、哮喘患者及健康受试者静息状态下测定肺功能后行极量运动负荷试验,终止后1MIN起,每5MIN检测一次FEV1.0,共1H,待受试者FEV1.0恢复至运动前水平,再吸入特布他林2喷(0.25MG/喷)15MIN后,检测其FEV1.0.结果:哮喘组运动后FEV1.0下降明显,COPD组运动后略有下降,健康人组运动后无明显改变.吸药后15MIN,哮喘组改善率明显高于COPD组及健康人组.哮喘组运动负荷实验后FEV1.0与其吸入特布他林后改善率有明显相关性.结论:哮喘患者运动负荷后气道反应性和对β2－受体激动剂的反应性存在较大的个体差异,运动负荷试验后气道反应性高者,β2－受体激动剂疗效较好.“,”Objective: Our aim was to study the relationship of exercise challenge induced airway hyperresponsiveness (AH) and 2agonist (Bricasol) inhalation effect in patients with COPD and asthma as well as normal people. Methods: First, measurement of pulmonary function was performed. Then, exercise challenge test was carried out by computer controlled bicycle ergomoter. The FEV1.0 was recorded every 5 minutes for an hour for every patient and control. When FEV1.0 ...