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目的探讨米非司酮治疗更年期功能失调性子宫出血患者的临床疗效。方法选取2013年1月至12月就诊的更年期功能失调性子宫出血患者资料152例,按随机数字表法将其分为观察组和对照组,各76例。对照组患者口服醋酸甲羟孕酮和己烯雌酚,观察组患者口服米非司酮,比较两组患者的临床疗效、治疗后1年的复发率以及性激素水平。结果观察组患者总有效率明显高于对照组,治疗后1年的复发率明显低于对照组,差异均有统计学意义(均P<0.05);观察组患者的E2、黄体酮均明显低于对照组,差异均有统计学意义(均P<0.05)。结论采用米非司酮治疗更年期功能失调性子宫出血临床效果明显,复发率低,能够使E2和黄体酮明显下降。
Objective To investigate the clinical efficacy of mifepristone in the treatment of menopausal dysfunctional uterine bleeding patients. Methods A total of 152 patients with dysfunctional uterine bleeding in menopause were selected from January to December in 2013. The data were divided into observation group and control group according to the random number table method, 76 cases in each group. Patients in the control group were treated with medroxyprogesterone acetate and diethylstilbestrol. The patients in the observation group were given oral mifepristone. The clinical efficacy, recurrence rate at 1 year after treatment, and sex hormone level were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group, and the recurrence rate at 1 year after treatment was significantly lower than that in the control group (all P <0.05). E2 and progesterone in the observation group were significantly lower In the control group, the differences were statistically significant (all P <0.05). Conclusion Mifepristone treatment of menopausal dysfunctional uterine bleeding has obvious clinical effect, low recurrence rate, can make E2 and progesterone significantly decreased.