This paper reports our experience with a new overthe-scope clip in the setting of recurrent bleeding and oesophageal fistula. We treated five patients with the over-the-scope Padlock Clip?. It is a nitinol ring, with six inner needles preassembled on an applicator cap, thumb press displaced by the Lock-It? delivery system. The trigger wire is located alongside the shaft of the endoscope, and does not require the working channel. Three patients had recurrent bleeding lesions(bleeding rectal ulcer, post polypectomy delayed bleeding and duodenal Dieulafoy’s lesion) and two patients had a persistent respiratory-esophageal fistula. In all patients a previous endoscopic attempt with standard techniques had been useless. All procedures were conducted under conscious sedation but for one patient that required general anaesthesia due to multiple comorbidities. We used one Padlock Clip? for each patient in a single session. Simple suction was enough in all of our patients to obtain tissue adhesion to the instrument tip. A remarkably short application time was recorded for all cases(mean duration of the procedure: 8 min). We obtained technical and immediate clinical success for every patient. No major immediate, early or late(within 24 h, 7 d or 4 wk) adverse events were observed, over follow-up durations lasting a mean of 109.4 d. One patient, treated for duodenal bulb bleeding from a Dieulafoy’s lesion, developed signs of mild pancreatitis 24 h after the procedure. The new over-the-scope Padlock Clip? seems to be simple to use and effective in different clinical settings, particularly in “difficult” scenarios, like recurrent bleeding and respiratory-oesophageal fistulas. This paper reports our experience with a new overthe-scope clip in the setting of recurrent bleeding and oesophageal fistula. We treated five patients with the over-the-scope Padlock Clip®. It is a nitinol ring, with six inner needles preassembled on an applicator cap, thumb press displaced by the Lock-It? delivery system. The trigger wire is located alongside the shaft of the endoscope, and does not require the working channel. Three patients had recurrent bleeding lesions (bleeding rectal ulcer, post polypectomy late bleeding and duodenal Dieulafoy’s lesion) and two patients had a persistent respiratory-esophageal fistula. All procedures were conducted under conscious sedation but for one patient that required general anaesthesia due to multiple comorbidities. We used one Padlock Clip? For each patient in a single session. Simple suction was enough in all of our patients to obtain tissue adhesi On the instrument tip. A remarkably short application time was was recorded for all cases (mean duration of the procedure: 8 min). We obtained technical and immediate clinical success for every patient. No major immediate, early or late (within 24 h, 7d or 4 wk) adverse events were observed, over follow-up durations lasting a mean of 109.4 d. One patient, treated for duodenal bulb bleeding from a Dieulafoy’s lesion, developed signs of mild pancreatitis 24 h after the procedure. The new over -the-scope Padlock Clip? seems to be simple to use and effective in different clinical settings, particularly in “difficult ” scenarios, like recurrent bleeding and respiratory-oesophageal fistulas.