目的探讨牙髓病和根尖周炎患牙用Cortisomol糊剂(碧兰糊剂)充填根管后的疼痛发生率及临床疗效。方法选择160例牙髓病、根尖周病患者,175颗患牙,随机分为两组。实验组用碧兰糊剂加牙胶尖根管充填,对照组用碘仿氧化锌糊剂加牙胶尖根管充填。观察术后1周内疼痛发生情况及术后3个月、1年疗效。结果根充术后1周实验组术后疼痛发生率较对照组低,差异有统计学意义(P<0.05);根充术后3个月实验组疗效高于对照组,但无显著性差异(P>0.05)。根充后1年,实验组疗效明显高于对照组,差异有统计学意义(P<0.05)。结论碧兰糊剂用于根管充填治疗可有效减轻根充术后疼痛,提高治疗效果。 Objective To investigate the incidence of pain and clinical efficacy of endodontic and periapical periodontitis patients treated with Cortisomol paste (Pitt Paste). Methods 160 cases of endodontic disease, apical periodontal disease and 175 teeth were randomly divided into two groups. The experimental group was filled with Pitini paste gutta-percha root canal, while the control group was filled with iodoform-type zinc oxide paste and gingival apical root canal. The incidence of pain within 1 week after operation and 3 months and 1 year after operation were observed. Results The postoperative incidence of postoperative pain in the experimental group was significantly lower than that in the control group at 1 week after root filling (P <0.05). The effect of the experimental group at 3 months after root filling was higher than that in the control group, but there was no significant difference (P> 0.05). One year after root filling, the experimental group was significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusion Brine paste for root canal filling treatment can effectively reduce postoperative root canal pain and improve the therapeutic effect.