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作者对84例(女性63例、男性21例)系统性硬化症(Systemic Sclerosis)病人进行了研究和观察,时间长达15年。这些病人的年龄为21～74岁。除3例以外,其他所有病人均有肢端动脉痉挛现象。结果发现,主要系统侵犯的发生率为食道(73％)、心脏(49％)、肺(46％)和肾(41％)。在能够准确估计从肢端动脉痉挛现象发生到出现皮肤改变的间隔时间的病人中,男性病人(17例)于肢端动脉痉挛现象发生的2年内,均出现了皮肤症状,而女性病人(45例)的间隔时间可长达29年,女性的平均间隔时间(5.1±7.0年)比男性(0.25±0.8年)长得多。这种差异具有非常显著意义(P<0.005)。在研究期间,21例男性病人中死亡7例(占33％),
The authors studied and observed 84 patients (63 female and 21 male) with Systemic Sclerosis over a 15-year period. These patients are 21 to 74 years of age. Except for 3 cases, all other patients had arterial spasm. The results showed that the incidence of major systemic violations was esophagus (73%), heart (49%), lung (46%) and kidney (41%). Among the patients who were able to accurately estimate the time from the occurrence of arterial spasm to the time of skin change, 17 patients had skin symptoms within 2 years after the onset of arterial spasm, whereas female patients (45 For example) can last up to 29 years, and the average interval between women (5.1 ± 7.0 years) is significantly longer than that of men (0.25 ± 0.8 years). This difference is very significant (P <0.005). During the study period, 7 of 21 male patients (33%) died,