Leigh病(LD)即亚急性坏死性脑脊髓病,是一种少见的、病因不明的常染色体隐性遗传性神经系统变性疾患,为脑脊髓灰质及白质病变,CT常示双侧对称性基底节低密度灶,主要累及婴儿及儿童。 一、临床表现 常有精神运动发育迟缓,情绪无节制,可有睡眠障碍,在病毒感染后出现发育缓慢,体重及身高常低于正常,学走晚,呼吸困难, Leigh’s disease (LD), subacute necrotizing encephalomyelopathy, is a rare, autistic, autosomal recessive neurodegenerative disease of the etiology. It is cerebral gray matter and white matter disease. CT is often associated with bilateral symmetrical basement Low-density section of the stove, mainly involving infants and children. First, the clinical manifestations often mental retardation, emotional incontinence, may have sleep disorders, slow development after the virus infection, weight and height often lower than normal, learn to go late, dyspnea,