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大鼠口服菊花、郁金及刺五加水煎剂(剂量按药典成人用量折算)三周后,抑制其肝微粒体羟甲基戊二酰辅酶A还原酶的活力,并激活肝微粒体胆固醇7α-羟化酶。在相同状况下,首乌及川芎可抑制羟甲基戊二酰辅酶A还原酶,虽然对胆固醇7α-羟化酶亦有激活作用,但统计学上无意义。泽泻、蒲黄、丹参、黄精、虎杖、延胡索及菌陈等则只抑制肝微粒体羟甲基戊二酰辅酶A还原酶,而对胆固醇7α-羟化酶无作用。黄芪及枸杞对肝微粒体羟甲基戊二酰辅酶A还原酶的活力虽然稍有激活作用,但统计学上无意义。我们实验状况下,上述十五种中药只有菌陈能显著地提高大鼠血清高密度酯蛋白胆固醇的含量。刺五加水煎液对肝微粒体羟甲基戊二酰辅酶A还原酶和胆固醇7α-羟化酶活力调节作用是通过可逆的磷酸化及脱磷酸化作用而实现的。 山楂及刺五加水煎剂,在体外对大鼠肝微粒体羟甲基戊二酰辅酶A还原酶具有强烈的抑制作用。其作用机理亦是通过可逆的磷酸化及脱磷酸化作用进行的。
Three weeks after oral administration of chrysanthemum, turmeric and Acanthopanax senticosus decoction (dose according to the Pharmacopoeia dosage) rats inhibited the activity of liver microsomal hydroxymethyl glutaryl coenzyme A reductase and activated hepatic microsomal cholesterol 7α - hydroxylase. Under the same conditions, Polygonum multiflorum and Rhizoma Chuanxiong inhibited hydroxymethylglutaryl coenzyme A reductase, which was statistically insignificant although it also had an activation effect on cholesterol 7α-hydroxylase. Alisma orientalis, Puhuang, Salvia miltiorrhiza, Polygonum cuspidatum, Polygonum cuspidatum, Rhizoma Corydalis and Bacillus subtilis only inhibit liver microsomal hydroxymethylglutaryl coenzyme A reductase, but have no effect on cholesterol 7α-hydroxylase. Astragalus and Chinese wolfberry liver microsomal hydroxymethyl glutaryl coenzyme A reductase activity although slightly activated, but statistically meaningless. Under our experimental conditions, only Shi Chen of the above fifteen traditional Chinese medicines can significantly increase serum high density ester protein cholesterol in rats. Acanthopanacis decoction of liver microsomal hydroxymethyl glutaryl coenzyme A reductase and cholesterol 7α-hydroxylase activity through reversible phosphorylation and dephosphorylation effect achieved. Hawthorn and Acanthopanax senticosus decoction, in vitro rat liver microsomal hydroxymethyl glutaryl coenzyme A reductase has a strong inhibitory effect. Its mechanism of action is also through reversible phosphorylation and dephosphorylation.