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目的探讨内皮素在肾病综合征发生、发展过程中的意义。方法应用放射免疫法检测２１例肾病综合征（ＮＳ）患儿急性期、缓解期及１０例健康小儿静脉血中内皮素（ＥＴ）浓度。结果ＮＳ患儿血中ＥＴ水平急性期明显高于对照组（Ｐ＜０．０１），亦明显高于缓解期（Ｐ＜０．０１）；缓解期血液ＥＴ水平略高于对照组，但无显著性差异（Ｐ＞０．０５）。结论ＥＴ在ＮＳ发生、发展过程中起着重要作用，动态观察ＥＴ水平对掌握病情有一定意义
Objective To investigate the significance of endothelin in the occurrence and development of nephrotic syndrome. Methods Radioimmunoassay was used to detect the concentration of endothelin (ET) in 21 children with nephrotic syndrome (NS) at acute and remission stage and 10 healthy children. Results The serum levels of ET in acute stage of NS children were significantly higher than those in control group (P <0.01), and also significantly higher than those in remission stage (P <0.01). ET level in remission group was slightly higher than that in control group Significant difference (P> 0.05). Conclusion ET plays an important role in the occurrence and development of NS. The dynamic observation of ET level has some significance to the control of the disease