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目的分析转化生长因子β1(TGF-β1)基因多态性与结直肠癌的相关性。方法选取2008年1月至2013年1月间诊治的109例结直肠癌患者为观察组,120例健康体检者作为对照组。分析对比两组TGF-β1基因多态性及其与结直肠癌的相关性。结果两组TGF-β1 869C及869T等位基因频率差异无统计学意义(P>0.05)。观察组患者TGF-β1的509T等位基因频率显著高于对照组(χ~2=6.109,P=0.013)。Logistic回归分析显示,携带TGF-β1(509T)基因是发生结直肠癌的独立危险因素(OR=3.512,95%CI为2.136~5.641)。结论 TGF-β1 509基因与结直肠癌发病相关,其T等位基因可能是结直肠癌发病的危险因素。
Objective To analyze the association between TGF-β1 gene polymorphism and colorectal cancer. Methods A total of 109 patients with colorectal cancer diagnosed and treated between January 2008 and January 2013 were selected as observation group and 120 healthy subjects as control group. Analysis and comparison of the two groups of TGF-β1 gene polymorphism and its correlation with colorectal cancer. Results There was no significant difference in the frequencies of TGF-β1 869C and 869T between the two groups (P> 0.05). The 509T allele frequency of TGF-β1 in observation group was significantly higher than that in control group (χ ~ 2 = 6.109, P = 0.013). Logistic regression analysis showed that TGF-β1 (509T) gene was an independent risk factor for colorectal cancer (OR = 3.512, 95% CI 2.136-5.641). Conclusion The TGF-β1 509 gene is associated with the pathogenesis of colorectal cancer. The T allele may be the risk factor of colorectal cancer.