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目的:探讨急性脑梗死患者溶栓前D-二聚体浓度与脑梗死发病至就诊时间、脑梗死症状严重程度、症状改善情况之间的关系。方法:研究纳入了117例患者,依据入院时D-二聚体浓度,将患者分为D-二聚体<0.55 mg/L组(正常组)与D-二聚体≥0.55 mg/L组(异常组),比较两组在发病至就诊时间、溶栓前美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、溶栓后NIHSS评分改善程度之间的差异。结果:两组在发病至就诊时间上差异无统计学意义[(122.4±57.5)min vs.(116.6±59.4)min,P>0.05],正常组溶栓前NIHSS评分明显低于异常组[(9.6±6.8)分vs.(17.4±9.2)分,P<0.05],两组在溶栓后NIHSS评分改善程度之间差异无统计学意义[(3.6±5.4)分vs.(5.0±7.6)分,P>0.05]。结论:不同D-二聚体浓度与发病至就诊时间无明显关系,D-二聚体异常组入院时NIHSS评分显著高于正常组,两组在溶栓后NIHSS评分的改善程度上差异无统计学意义。
Objective: To investigate the relationship between the concentration of D-dimer before thrombolytic therapy and the onset time of cerebral infarction, the severity of cerebral infarction and the improvement of symptoms in patients with acute cerebral infarction. Methods: A total of 117 patients were enrolled in this study. Patients were divided into D-dimer <0.55 mg / L group (normal group) and D-dimer> 0.55 mg / L group according to the concentration of D-dimer on admission (Abnormal group). The differences between the NIHSS scores and the National Institutes of Health Stroke Scale (NIHSS) score before thrombolysis and before the thrombolysis were compared between the two groups. Results: There was no significant difference between the two groups in the time of onset and treatment [(122.4 ± 57.5) min vs. (116.6 ± 59.4) min, P> 0.05). NIHSS scores in the normal group were significantly lower than those in the abnormal group [ 9.6 ± 6.8) vs (17.4 ± 9.2), P <0.05]. There was no significant difference between the two groups in NIHSS score improvement after thrombolysis (3.6 ± 5.4 vs 5.0 ± 7.6) Points, P> 0.05]. CONCLUSION: There is no significant relationship between the different D-dimer concentrations and the time from onset to treatment. The NIHSS scores in the D-dimer group were significantly higher than those in the normal group on admission, and there was no significant difference in NIHSS score between the two groups Significance of learning.