遗传性视网膜母细胞瘤的易感性以显性方式传递,现已将决定该肿瘤易感基因(RB)定位于13q14,与酯酶D基因紧密连锁。有人认为RB基因的两个等位基因都失活时,即可导致视网膜母细胞瘤的发生。在一些视网膜母细胞瘤中,13q14有分子缺失,证明RB基因在细胞水平上是以“隐性”方式起作用的,与用转染等方法检测出 The susceptibility of hereditary retinoblastoma is transmitted in a dominant manner, and it has now been determined that this tumor susceptibility gene (RB) is localized at 13q14 and is tightly linked to the esterase D gene. Some people believe that when the two alleles of the RB gene are inactivated, retinoblastoma can occur. In some retinoblastomas, there is a molecular loss of 13q14, demonstrating that the RB gene functions at the cellular level in a “hidden” manner, as detected by methods such as transfection.