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目的初步了解本地区孕妇这一特殊人群乙型肝炎病毒(HBV)感染情况,同时观察HBV感染孕妇不同阳性模式组合丙氨酸转氨酶的变化。方法采用微粒子化学发光法检测2 356例孕妇血清中HBs Ag、HBs Ab、HBe Ag、HBe Ab、HBc Ab 5项乙肝标志物,同时采用酶速率法检测丙氨酸转氨酶,并对结果进行统计分析。结果 2 356例孕妇检出HBs Ag阳性者137例,占5.81%,表面抗体986例,占41.85%,大三阳HBs Ag(+)、HBe Ag(+)、HBc Ab(+)的检出率为2.63%,小三阳HBs Ag(+)、HBe Ab(+)、HBc Ab(+)的检出率为1.91%。不同年龄组的HBs Ag检出率差异无统计学意义(P>0.05)。HBV-DNA阳性率和丙氨酸转氨酶异常增高率,在大三阳孕妇患者的血清中检出率明显高于其他2组。结论本地区孕妇感染HBV比率为4.3%,HBV-DNA阳性率和丙氨酸转氨酶异常增高率在HBe Ag阳性的孕妇中高于HBe Ag阴性的孕妇。
Objective To understand the status of hepatitis B virus (HBV) infection in this special population of pregnant women in this area and to observe the changes of alanine aminotransferase (ALT) in different positive modes of HBV infection pregnant women. Methods Serum HBs Ag, HBs Ab, HBe Ag, HBe Ab and HBc Ab were detected by microparticle chemiluminescence in five hepatitis B markers. The enzyme-linked immunosorbent assay (ELISA) was used to detect the alanine aminotransferase and the results were statistically analyzed . Results A total of 2 356 HBsAg positive cases were detected in 137 males (5.81%) and 986 (41.85%) HBsAg positive cases. HBs Ag (+), HBe Ag (+) and HBc Ab The rate of HBsAg (+), HBeAb (+) and HBcAb (+) was 1.63% with a rate of 2.63%. There was no significant difference in the detection rate of HBsAg between different age groups (P> 0.05). The positive rate of HBV-DNA and abnormal increase of alanine aminotransferase were significantly higher in the serum of pregnant women than in the other two groups. Conclusion The HBV infection rate of pregnant women in this area is 4.3%. The positive rate of HBV-DNA and abnormal increase rate of alanine aminotransferase are higher in HBeAg-positive pregnant women than in HBeAg-negative pregnant women.