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目的制备甲睾酮聚乳酸微球,研究其体外释药过程。方法采用乳化-溶剂挥发法制备甲睾酮聚乳酸微球;以0.25%SDS-5%乙醇(pH3.4)为释放介质,采用高效液相色谱法测定甲睾酮聚乳酸微球的体外释药量。结果甲睾酮聚乳酸微球开始释药较快,存在一定突释效应,随后以缓慢的方式释药,可用双相动力学方程100-R=35.77e0.1321t+63.91e7.372E-4t描述。结论制成的甲睾酮聚乳酸微球具有明显的缓释作用。
Objective To prepare methyltestosterone polylactide microspheres and study its in vitro release process. Methods Methyltestosterone polylactic acid microspheres were prepared by emulsion-solvent evaporation method. The release rate of methyltestosterone polylactic acid microspheres in vitro was measured by HPLC with 0.25% SDS-5% ethanol (pH3.4) . Results Methyltestosterone polylactic acid microspheres began to release faster, there is a certain burst effect, and then release the drug in a slow manner, described by the biphasic kinetic equation 100-R = 35.77e0.1321t + 63.91e7.372E-4t. Conclusion Methyltestosterone polylactic acid microspheres have obvious sustained release effect.