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目的观察血清微小RNA-21-5p(miRNA-21-5p)预测急性心力衰竭(AHF)患者近期预后的价值。方法 AHF患者110例,qRT-PCR检测血清miRNA-21-5p、miRNA-129和miRNA-320a的表达量,并随访100d内患者的生存情况。结果 110例患者中,随访期死亡18例,生存92例。死亡病例血清miRNA-21-5p相对表达量低于生存病例(P<0.05),而miRNA-129和miRNA-320a相对表达量差异无统计学意义(P>0.05)。取血清miRNA-21-5p相对量0.724作为最佳临界值,其预测AHF患者发病100d内发生死亡的敏感度为70.3%,特异度为63.2%。miRNA-21-5p相对含量<0.724者的生存率低于miRNA-21-5p相对含量≥0.724者(P<0.01)。结论检测血清miRNA-21-5p水平有助于预测AHF患者的预后。
Objective To investigate the prognostic value of serum microRNA-21-5p (miRNA-21-5p) in patients with acute heart failure (AHF). Methods 110 patients with AHF were enrolled in this study. The expression of miRNA-21-5p, miRNA-129 and miRNA-320a were detected by qRT-PCR and the patients were followed up for 100 days. Results Of the 110 patients, 18 died and 92 survived during the follow-up period. The relative expression of miRNA-21-5p in serum of death patients was lower than that of survivors (P <0.05), while the relative expression of miRNA-129 and miRNA-320a was not statistically significant (P> 0.05). Taking the relative amount of serum miRNA-21-5p 0.724 as the optimal cut-off value, the sensitivity and the specificity of predicting the death of AHF within 100 days after onset were 70.3% and 63.2% respectively. The relative survival rate of miRNA-21-5p <0.724 was lower than that of miRNA-21-5p> 0.724 (P <0.01). Conclusion Detection of serum miRNA-21-5p levels is helpful to predict the prognosis of patients with AHF.