环孢霉素A(cyclosporin A)是一种从霉菌中提取出来的具有免疫抑制作用的药物,它的应用使大型器官移植获得成功。全身应用也有与其它同类药物一样的副作用,但局部应用则对于防止角膜移植反应十分有效。Mosteller等实验证明,用环孢霉素A滴眼,药液能穿过角膜实质以至内皮,达到治疗所需浓度。在家兔眼模型上,球后注射2％环孢霉素A或 Cyclosporin A (cyclosporin A) is an immunosuppressive drug extracted from mold and its use has enabled the success of large organ transplantation. Systemic applications also have the same side effects as other similar drugs, but topical application is very effective in preventing corneal graft response. Mosteller experiments show that with cyclosporin A eye drops, liquid medicine can penetrate the cornea and endothelium, to achieve the desired concentration for treatment. In a rabbit eye model, 2% cyclosporin A or a ball was injected after the ball