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目的了解甘肃省接受高效抗反转录病毒治疗(HAART)的艾滋病(AIDS)病人CD+4T淋巴细胞(简称CD4细胞)的变化趋势,分析不同性别、年龄、感染途径治疗人群的治疗效果是否存在差异。方法利用SPSS 19.0描述艾滋病病毒(HIV)感染者/AIDS病人(简称HIV/AIDS病人)CD4细胞在治疗后5年内不同时间点上的分布情况,使用混合效应线性模型拟合CD4细胞计数与性别、年龄、感染途径等因素之间的关系。结果选取103例HIV/AIDS病人,男性占67.96%,女性占32.04%;治疗开始年龄以21~50岁为主,占86.41%;感染途径以性接触传播为主,占68.93%。开始治疗前病人CD4细胞中位数为156个/μL,治疗1、2、3、4、5年后,CD4细胞中位数分别为290个/μL、309个/μL、344个/μL、347个/μL、525个/μL。CD4细胞计数与治疗时间和开始治疗时CD4细胞水平正相关;性别和治疗开始年龄没有显著性差异;经男男性行为和血液途径感染的艾滋病病人治疗效果存在统计学差异(P<0.05)。结论甘肃省接受HAART治疗的艾滋病病人在5年内CD4细胞计数有上升趋势,男男性行为感染者的治疗效果较经血液感染者好。
Objective To investigate the trend of CD + 4T lymphocytes (CD4 cells) in AIDS patients receiving HAART in Gansu province and analyze whether the treatment effect exists in different sexes, ages and routes of infection difference. Methods The distribution of CD4 cells in HIV / AIDS patients (HIV / AIDS patients) at different time points within 5 years after treatment was described by SPSS 19.0. A mixed effect linear model was used to fit CD4 cell counts and sex, Age, the route of infection and other factors. Results A total of 103 HIV / AIDS patients were selected, accounting for 67.96% for males and 32.04% for females. The age at the start of treatment ranged from 21 to 50 years, accounting for 86.41%. Sexually transmitted infections accounted for 68.93%. The median CD4 cell count was 156 cells / μL before treatment, and the median CD4 cell count was 290 cells / μL, 309 cells / μL, 344 cells / μL after 1, 2, 3, 347 / μL, 525 / μL. CD4 cell count was positively correlated with treatment time and the level of CD4 cells at the beginning of treatment; there was no significant difference between the sex and age at the start of treatment; there was a significant difference (P <0.05) in the treatment effect of AIDS patients infected by MSM and blood. Conclusion AIDS patients receiving HAART in Gansu Province have an increasing trend of CD4 cell count within 5 years, and those with MSM infection are better than those with blood-infected people.