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在阿霉素引起细胞自由基损伤的大鼠模型上观察了灵芝的保护作用。隔日ｉｐ阿霉素３ｍｇ／ｋｇ４次制造细胞自由基损伤的大鼠模型，以实验大鼠血液与心脏、肝脏中ＳＯＤ和ＧＳＨＰｘ活性为观察指标。结果表明阿霉素可明显降低实验大鼠血液与心脏、肝脏中ＳＯＤ和ＧＳＨＰｘ活性。ｉｇ灵芝两周可抑制阿霉素的这一作用并呈现一定的剂量依赖关系。灵芝对血液中ＳＯＤ和ＧＳＨＰｘ活性不仅可使之恢复至原水平，甚至有所提高。而对心、肝组织，灵芝需在较大剂量才可使其ＳＯＤ和ＧＳＨＰｘ活性恢复至接近原水平。表明灵芝可在一定程度上抑制阿霉素引起细胞自由基损伤作用。
The protective effect of Ganoderma lucidum was observed in a rat model of adriamycin-induced cellular free radical damage. The other day ip doxorubicin 3mg / kg 4 times the manufacture of cell free radical injury rat model to rat blood and heart, liver SOD and GSH Px activity as an indicator. The results showed that doxorubicin can significantly reduce the experimental rat blood and heart, liver SOD and GSH Px activity. ig two weeks Ganoderma can inhibit this effect of doxorubicin and showed a certain dose-dependent relationship. Ganoderma lucidum on the blood SOD and GSH Px activity can not only restore the original level, and even increased. The heart, liver, Ganoderma lucidum required a larger dose before its SOD and GSH Px activity restored to near the original level. Show that Ganoderma lucidum can inhibit doxorubicin to some extent caused by cell damage of free radicals.