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目的:分析智力低下的病因与染色体畸变和细胞微核率变化的关系。方法:应用常规外周血淋巴细胞染色体G显带技术进行染色体核型分析和细胞微核率检测。结果:32例受检者中,检出异常核型13例,检出率为40.63%。实验组微核发生率为11.91%,对照组微核发生率为3.42%,两组微核发生率比较有统计学差异(P<0.01)。结论:染色体异常及微核形成是导致智力低下的重要遗传学原因,微核形成与环境因素有关。
Objective: To analyze the relationship between the cause of mental retardation and chromosomal aberration and the change of cell micronucleus rate. Methods: Chromosome karyotype analysis and micronucleus test were performed by conventional peripheral blood lymphocyte chromosome G banding technique. Results: Of the 32 subjects, 13 cases were detected abnormal karyotype, the detection rate was 40.63%. The incidence of micronuclei in the experimental group was 11.91%, while that of the control group was 3.42%. The incidence of micronuclei in the two groups was statistically different (P <0.01). Conclusion: Chromosomal abnormalities and micronuclei formation are the important genetic causes of mental retardation. Micronuclei formation is related to environmental factors.