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目的 探讨多发性硬化患者脑脊液 (CSF)一氧化氮 (NO)含量变化。方法 采用硝酸还原酶法检测 4 3例多发性硬化 (MS)患者、2 5例吉兰 巴雷综合症 (GBS)患者及 39例对照者CSF的NO水平 ,同时进行其生化和细胞学成分及寡克隆IgG区带 (IgG OB)分析。 结果 MS组CSF的NO水平明显高于对照组 (P<0 .0 1)。结论 硝酸还原酶法能快速、准确地检测CSF的NO含量 ;NO参与了MS的免疫发病机制 ,并在一定程度上反映机体细胞免疫的状态。
Objective To investigate the changes of cerebrospinal fluid (CSF) nitric oxide (NO) in patients with multiple sclerosis. Methods Nitric acid reductase was used to detect the level of NO in 43 patients with multiple sclerosis (MS), 25 patients with Guillain-Barre syndrome (GBS) and 39 controls. The biochemical and cytological parameters and Oligoclonal IgG band (IgG OB) analysis. Results The level of NO in CSF of MS group was significantly higher than that of control group (P <0.01). CONCLUSION Nitric acid reductase method can rapidly and accurately detect the content of NO in CSF. NO participates in the pathogenesis of MS and reflects the cellular immune status to a certain extent.