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一组第一次列入“慢性肝炎”的35例患儿,经过组织学的研究,只有16例证实属于慢性肝炎:3例为慢性迁延性肝炎(1型),6例慢性活动性肝炎(2a型)7例为慢性活动性肝炎(2b型)。正如以前所报导的,以女性占多数,发病率随年龄而增高。16例儿童中只有4例有急性肝炎病史,测定乙型肝炎抗原的9例中只有3例是阳性。慢性迁延性肝炎的病情演进是良好的,而慢性活动性肝炎则伴有组织学的进行性改变。根据这一理由将后一组应用大剂量和长疗程的皮质激素治疗。经对照研究,提示有一个较长的存活期。
Of the 35 children initially included in the group of “chronic hepatitis”, only 16 of the 35 patients with chronic hepatitis were confirmed as having chronic hepatitis: 3 with chronic persistent hepatitis (type 1) and 6 with chronic active hepatitis 2a type) 7 cases of chronic active hepatitis (2b type). As previously reported, women were predominant and the incidence increased with age. Only 4 of 16 children had a history of acute hepatitis and only 3 of 9 patients who tested for hepatitis B antigen were positive. The progression of chronic persistent hepatitis is good, while chronic active hepatitis is accompanied by a progressive change in histology. According to this reason, the latter group will be treated with high dose and long course of corticosteroids. After a controlled study, suggesting a longer survival period.