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肿瘤转移在肿瘤发展进程中具有十分重要的作用。恶性肿瘤患者很少死于原发癌，绝大多数死于肿瘤转移。目前对于肿瘤转移的机理了解甚少，也缺乏有效的控制和治疗手段。１９９５年Dong犤１犦首次发现的肿瘤转移抑制基因KAI１以及近年来对其机理的研究取得了新进展，研究表明该基
Tumor metastasis has a very important role in the development of tumors. Patients with malignant tumors seldom die from primary cancer, and most of them die from tumor metastasis. At present, little is known about the mechanism of tumor metastasis, and there is also lack of effective control and treatment methods. The first discovery of tumor metastasis suppressor KAI1 in Dongyang in 1995 and the recent progress in its mechanism have led to new advances in research.