Ischemia/reperfusion (I/R)is a pathological process that occurs in numerous organs throughout the human body,and it is frequently associated with severe cellular damage and death.Recently it has emerged that ferroptosis,a new form of regulated cell death that is caused by iron-dependent lipid peroxidation,plays a significantly detrimental role in many I/R models.In this review,we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis.Furthermore,we aim to evaluate the role that ferroptosis plays in I/R,providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury (IRI) associated cell damage and death.