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目的:研究血型抗体效价与新生儿溶血病的关系。方法:从济南市妇幼保健院选择2010年1～6月1 096例孕16周以上血型为O型Rh阳性孕妇,且丈夫为A型Rh阳性、B型Rh阳性或AB型Rh阳性者做血型抗体效价,并跟踪观察出生后新生儿溶血病的发生情况。结果:血型抗体效价与新生儿溶血病有直接关系,血型抗体效价高于正常的孕妇所分娩的新生儿发生溶血的几率大。但血型抗体效价的高低与溶血的严重程度无直接关系。可能与下列情况有关:新生儿抽血的时间不一致、治疗情况不同、母亲未妊娠前抗体效价的基数。结论:孕妇血型抗体效价异常可能引起新生儿溶血病。
Objective: To study the relationship between blood group antibody titers and hemolytic disease in newborns. Methods: From January to June of 2010, 1 096 pregnant women of more than 16 weeks of pregnancy were selected as O type Rh positive pregnant women, and her husband was type A Rh positive, type B Rh positive or type AB Rh positive. Antibody titer, and follow-up observation of neonatal hemolytic disease after birth. Results: The titer of blood group antibody was directly related to hemolytic disease of neonates. The titer of blood group antibody was higher than that of newborn babies born by normal pregnant women. However, the level of blood group antibody titers is not directly related to the severity of hemolysis. May be related to the following situations: neonatal bleeding time is inconsistent, the treatment is different, the mother before pregnancy antibody titer cardinality. Conclusion: Abnormal blood group antibody in pregnant women may cause neonatal hemolytic disease.