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目的:探讨急性冠脉综合征患者血清IL-10/IL-6水平及NF-κB活性变化。方法:采用ELISA法检测45例急性冠脉综合征(ACS)患者,20例稳定性心绞痛(SAP)患者,20例非冠心病为对照者血清IL-10、IL-6水平;同时细胞免疫组化测定各组外周血单个核细胞NF-κB活性。结果:ACS组血清IL-6/IL-10比值及NF-κB活性均高于SAP组及对照组(ACS:1.69±0.53,0.32±0.12;SAP:1.06±0.38,0.13±0.07;对照组:0.92±0.41,0.11±0.09,均P<0.05)。结论:炎症介质及抗炎症介质分泌失衡在急性冠脉综合征中发挥了重要作用。
Objective: To investigate the changes of serum IL-10 / IL-6 and NF-κB activity in patients with acute coronary syndrome. Methods: Serum levels of IL-10 and IL-6 in 45 patients with acute coronary syndrome (ACS), 20 patients with stable angina pectoris (SAP) and 20 patients with non-coronary heart disease were detected by ELISA. The activity of NF-κB in peripheral blood mononuclear cells of each group was measured. Results: The serum IL-6 / IL-10 ratio and NF-κB activity in ACS group were significantly higher than those in SAP group and control group (ACS: 1.69 ± 0.53,0.32 ± 0.12; SAP: 1.06 ± 0.38,0.13 ± 0.07; 0.92 ± 0.41,0.11 ± 0.09, all P <0.05). Conclusion: The imbalance of inflammatory mediators and anti-inflammatory mediators plays an important role in acute coronary syndrome.