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目的探讨乳腺癌中Fh it蛋白的表达状况及其与临床病理特征的关系。方法采用微波SP免疫组化方法检测Fh it蛋白在62例乳腺癌及正常乳腺组织中的表达。结果62例乳腺癌组织Fh it表达为36/62(58.1%),正常乳腺组织为60/62(96.7%),两者比较差异有统计学意义(P<0.05);伴有淋巴结转移的乳腺癌Fh it蛋白的阳性率为36%(9/25),无淋巴结转移为72.9%(27/37),两者比较,差异有统计学意义(P<0.05);Fh it蛋白的表达与组织学分级、肿瘤的大小无关(P>0.05)。结论Fh it表达可能与乳腺癌的淋巴结转移有关,Fh it表达缺失或降低是判断乳腺癌预后的重要指标。
Objective To investigate the expression of Fh it protein in breast cancer and its relationship with clinicopathological features. Methods Immunohistochemistry was used to detect the expression of Fhit protein in 62 cases of breast cancer and normal breast tissues. Results The expression of Fhit in 62 cases of breast cancer was 36/62 (58.1%) and that of normal breast was 60/62 (96.7%), the difference was statistically significant (P <0.05). The breast cancer with lymph node metastasis The positive rate of Fhit protein was 36% (9/25) and no lymph node metastasis was 72.9% (27/37), the difference was statistically significant (P <0.05) Learning grade, tumor size has nothing to do (P> 0.05). Conclusion The expression of Fhit may be related to the lymph node metastasis of breast cancer. The loss or decrease of Fhit expression is an important index to judge the prognosis of breast cancer.