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目的 建立一种简便、实用、可靠、易于普及的定量测定rCBF方法。方法 ①测定颅脑衰减系数 (δ) ;②平面像与断层像之间计数率转换比例因子 (ρ) ;③测定SPECT仪漏计 ;④测定肺滞留率 (Rl) ;⑤改良Nickel等的数学模型 ,编写计算机处理程序 ;⑥对正常志愿者 15例、患者组 9例 ,共2 4例定量测定rCBF。结果 δ =1 7,ρ =2 2 3 ,Rl<1% ;对照组rCBF范围为 (42 3± 4 6～ 5 7 5± 6 4 )mL·min-1·10 0g-1,8例癫痫患者病灶rCBF 2 2 5～ 3 4 2mL·min-1·10 0g-1,脑梗死病灶rCBF 7 2mL·min-1·10 0g-1。结论 方法简便实用 ,易于掌握 ,结果可靠 ,具有较高的临床应用价值。
Objective To establish a simple, practical, reliable and easy-to-use quantitative determination rCBF method. Methods ①Calculation of cranial brain attenuation coefficient (δ); ②Calculation ratio (ρ) of count rate conversion between planar image and tomographic image; ③Determination of leakage of SPECT instrument; ④Detection of lung retention rate (Rl); ⑤Modified Nickel’s mathematical Model, write computer processing program; ⑥ 15 cases of normal volunteers, 9 patients, a total of 24 cases quantitative determination of rCBF. RESULTS: The mean rCBF ranged from (42 3 ± 4 6 to 5 7 5 ± 6 4) mL · min -1 · 10 0g -1 in the control group to epilepsy Patients with lesions rCBF 2 2 5 ~ 34 2mL · min-1 · 10 0g-1, cerebral infarction rCBF 7 2mL · min-1 · 10 0g-1. Conclusion The method is simple and practical, easy to grasp, the result is reliable and has high clinical value.