棒酸是β-内酰胺酶的强抑制剂,其与羟氨苄青霉素联合应用引起肝损害的报道自1984年以来已有57例。本文复习了7例不同程度小叶间胆管病变及一例无肝组织学检查但有肝损,其中2例伴有肝外表现。其中男6例,女2例。8例患者分别因阻塞性肺病发作(4例)、胆绞痛伴发热(1例)、肺炎(1例)、支气管炎(1例)、根除幽门螺旋菌(1例)而使用该药,用量1.0～6g/d口服或静注,疗程7～15d,个别 Clavulanic acid is a potent inhibitor of β-lactamase. Combined with amoxicillin, hepatic damage has been reported in 57 cases since 1984. This review of seven cases of different degrees of interlobular bile duct lesions and a case without liver histology but with liver damage, including 2 cases with extrahepatic manifestations. Including 6 males and 2 females. Eight patients were treated with obstructive pulmonary disease (4 cases), biliary colic with fever (1 case), pneumonia (1 case), bronchitis (1 case) and eradication of H. pylori (1 case) Dosage 1.0 ~ 6g / d oral or intravenous, treatment 7 ~ 15d, individual