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目的观察高+G_x暴露对猴肾脏的损伤作用及恢复情况,为载人航天型号任务中可能遇到的高过载医学评价以及保障高过载人体试验安全提供依据。方法18只健康雄性成年恒河猴被随机分为对照组(n=2)、+15 G_x组(n=6)、+18 G_x组(n=3)和+21 G_x组(n=7),分别在离心机上承受相应峰值的抛物线型过载曲线作用,然后于不同时间进行尿检和解剖取材,用光学显微镜观察肾脏的病理学改变。结果①+G_x暴露后即刻,+15 G_x组、+18 G_x组和+21 G_x组猴分别出现了不同程度的尿潜血阳性、尿蛋白阳性,+21 G_x组出现尿潜血阳性的频率显著高于+15 G_x组(P＜0．05),其阳性程度也高于对照组和+15 G_x组(P＜0．01);②+G_x暴露后即刻,+15 G_x组、+18 G_x组和+21 G_x组猴肾脏分别出现了轻微、中度和较严重的病理损伤;③+15 G_x组、+18 G_x组猴肾功能改变和肾脏病理损伤在过载暴露后9 d基本恢复正常,+21 G_x组30 d基本恢复正常。结论高+G_x暴露可引起猴肾脏可恢复性损伤,且随着G值增加,损伤加重,恢复时间延长。
Objective To observe the injury and recovery of monkey kidney exposed to high + G_x exposure and provide the basis for high overload medical evaluation and safeguards of high overload human trials in the manned space mission. Methods Eighteen healthy male adult rhesus monkeys were randomly divided into control group (n = 2), + 15 G_x group (n = 6), + 18 G_x group (n = 3) and +21 G_x group , Respectively, in the centrifuge to withstand the corresponding peak parabolic overload curve, and then at different times for urine tests and anatomical material, using a light microscope to observe the pathological changes in the kidneys. Results ① Immediately after + G_x exposure, urinary occult blood was positive in all the groups of + 15 G_x, + 18 G_x and +21 G_x, with positive urinary protein, and the positive rate of urine occult blood in + 21 G_x group was significantly higher than that of + +15 G_x group (P <0.05), and the positive degree was also higher than that of the control group and the +15 G_x group (P <0.01). ② Immediately after + G_x exposure, +15 G_x group, +18 G_x group and +21 G_x group showed mild, moderate and severe histopathological damage respectively; ③The kidney function and renal pathological changes of +15 G_x and + 18 G_x groups returned to normal after 9 days of overload exposure, and +21 G_x group returned to normal after 30 days. Conclusions Exposure to high + G_x can cause recurrent injury in monkey kidney. With the increase of G value, the injury is aggravated and the recovery time prolonged.