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目的:探讨连续性血液滤过(CHF)对重症中暑患者内环境和生存率的影响。方法:2011-07-2013-08因重症中暑收入我院GICU患者42例,分为对照组(n=22)和研究组(n=20),观察2组患者体温、炎性递质及病死率情况。结果:2组治疗后1、6、24、48h体温下降比较,差异均有统计学意义(P<0.05)。治疗48h后,研究组炎性递质肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)显著降低,与对照组比较差异均有统计学意义(P<0.05)。结论:CHF能够改善重症中暑患者的预后,延长其存活时间,改善患者的生存率,其机制可能与早期快速降温,及时清除炎性递质有关。
Objective: To investigate the effect of continuous hemofiltration (CHF) on the internal environment and survival rate of patients with severe heat stroke. METHODS: Twenty-four patients with severe heat stroke who were admitted to our hospital with GICU were divided into control group (n = 22) and study group (n = 20). The body temperature, inflammatory neurotransmitters and death Rate situation. Results: There were significant differences in body temperature at 1, 6, 24 and 48 h after treatment (P <0.05). After 48 hours of treatment, the levels of TNF-α, IL-6 and IL-8 in the study group were significantly lower than those in the control group Significance (P <0.05). Conclusion: CHF can improve the prognosis, prolong the survival time and improve the survival rate of patients with severe heat stroke. The mechanism may be related to the early rapid cooling and the timely clearance of inflammatory neurotransmitters.