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目的 研究肿瘤侵袭程度与转移发生的关系.方法 选用可移植性肿瘤模型小鼠组织细胞肉瘤L_1,接种在近交系615小鼠爪垫内侧皮下,在肿瘤生长后1、3、5、10、20、30和40天分七批处死动物,组织学检查肿瘤侵袭程度和转移发生的关系.结果 肿瘤局部侵袭达Ⅲ～Ⅳ级时才发生肿瘤转移,早期出现引流淋巴结转移,肺转移出现时间晚于淋巴结转移.结论 根据肿瘤生长时间并结合侵袭转移程度与扩散范围,将肿瘤发展演进过程分为潜伏期、侵袭期和转移期,在肿瘤侵袭期,又可再分为侵袭早期、中期和晚期;在肿瘤转移期,也可再分为转移早期、中期和晚期.
Objective To investigate the relationship between the degree of tumor invasion and metastasis. Methods The tissue tumor sarcoma L_1 was transplanted into a mouse model of transplantable tumor and inoculated subcutaneously on the inner side of the paw pads of 615 inbred mice. After tumor growth 1, 3, 5, 10, The animals were sacrificed in seven batches on the 20th, 30th, and 40th days. Histologic examination of the relationship between tumor invasion and metastasis. Results Tumor metastasis occurred when tumors invaded locally from grades III to IV. Early lymph node metastasis occurred and lung metastasis occurred later In lymph node metastasis. Conclusion According to the tumor growth time combined with the degree of invasion and metastasis and diffusion range, the evolution process of tumor development is divided into incubation period, invasive period and metastasis period, and in the period of tumor invasion, it can be further divided into early, middle and late stages of invasion; In the tumor metastasis, it can also be divided into early, middle and late metastasis.