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自1962年第一个吡酮酸类抗菌药萘啶酸问世以来,许多学者致力于这类药物的结构改造以便寻找新的、抗菌谱更广、抗菌作用更强的药物。图1列出了已临床应用的和正在进行临床评价的这类药物的结构。
Since the advent of the first pyrazolic acid antibacterial nalidixic acid in 1962, many scholars have devoted themselves to the structural transformation of such drugs in order to find new drugs with broader antibacterial spectrum and stronger antibacterial activity. Figure 1 shows the structure of such drugs that have been clinically applied and undergoing clinical evaluation.