抑癌基因失活存在于多种肿瘤中 ,5′CpG岛高甲基化导致抑癌蛋白表达的减少与肿瘤发病率密切相关。本文总结了抑癌基因 5′CpG岛高甲基化的形成机制、在人类肿瘤中的发生率及相应的治疗对策 Inactivation of tumor suppressor gene exists in many tumors. The hypermethylation of 5’CpG island leads to the decrease of tumor suppressor protein expression and tumor incidence is closely related. This article summarizes the formation of tumor suppressor gene 5’CpG island hypermethylation, the incidence in human tumors and the corresponding treatment strategy