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目的 探讨微剂量肝素治疗急性白血病前弥漫性血管内凝血 (pre DIC)的疗效及其安全性。 方法 将 1997- 0 6～ 2 0 0 4 - 0 6佛山市第二人民医院急性白血病前DIC患者 36例 ,随机分成两组 ,微剂量肝素治疗组18例 (A组 ) ,常规治疗组 18例 (B组 )。结果 10d内 ,A组转化为DIC的患者少于B组 (P <0 0 5 ) ,D D二聚体转阴率A组高于B组 (P <0 0 5 )。结论 微剂量肝素治疗急性白血病前DIC状态能有效的阻止其向DIC发展 ,且具有良好的安全性。
Objective To investigate the efficacy and safety of micro-dose heparin in the treatment of diffuse intravascular coagulation (DIC) before acute leukemia. Methods Thirty-six patients with acute leukemia before DIC in Second People’s Hospital of Foshan from 1997- 2006 to 2004-06 were randomly divided into two groups, 18 patients in the micro-dose heparin group (group A) and 18 patients in the conventional treatment group (Group B). Results Within 10 days, the number of patients with DIC converted to DIC in group A was less than that in group B (P <0.05), and that in group D with D D dimer was higher than that in group B (P <0.05). Conclusion DIC treatment with DHA effectively prevents DIC from developing to DIC and has good safety.