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1例87岁女性患者因抽搐和心动过缓给予注射用丙戊酸钠1200 mg静脉持续泵入,20 ml/h,1次/d。用药前患者血小板计数为214×10~9/L。用药8 d后血小板计数降至63×10~9/L,停用注射用丙戊酸钠,改为口服丙戊酸钠缓释片500 mg,1次/d。5 d后患者血小板计数降至25×10~9/L。停用丙戊酸钠缓释片,输注血小板1 U,口服氨肽素1000 mg,3次/d。对症治疗8 d后血小板计数升至160×10~9/L。
One 87-year-old female patient was infused intravenously with 1200 mg sodium valproate intravenously for convulsions and bradycardia at 20 ml / h for 1 time / d. Patients before treatment platelet count 214 × 10 ~ 9 / L. After 8 d, the platelet count decreased to 63 × 10 ~ 9 / L. Sodium valproate for injection was discontinued. Oral sodium valproate sustained-release tablets were changed to 500 mg once daily. After 5 days, the patient’s platelet count decreased to 25 × 10 ~ 9 / L. Disable sodium valproate sustained-release tablets, platelet transfusion 1 U, oral aminopeptol 1000 mg, 3 times / d. After 8 days of symptomatic treatment, the platelet count rose to 160 × 10 ~ 9 / L.