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目的研究血清E_2、P以及β-HCG与妊娠早期孕妇先兆性流产的相关性。方法选取本院2013年4月~2015年4月期间收治的160例出现先兆流产症状的孕妇作为观察组,再选取300例经过检查显示正常的孕妇作为对照组。比较两组患者的血清E_2、P和β-HCG水平,分析激素下降与患者临床资料的相关性。结果两组患孕妇的年龄(t=0.619,P=0.536)、孕周(t=0.108,P=0.914)、BMI(t=0.452,P=0.651)以及初次妊娠的人数(χ~2=0.086,P=0.769)方面的比较均没有显著性差异;两组孕妇在<6w、6到8w、8到10w以及10到12w时血清中孕激素、人绒毛促性腺激素以及雌二醇浓度的比较均具有显著性差异。且由数据可以看出,随着孕周的逐渐推移,孕妇血清中孕激素、人绒毛促性腺激素以及雌二醇浓度也呈逐渐上升状态;孕妇血清激素的高低与孕妇的年龄(χ~2=9.151,P=0.002)和孕周(χ~2=10.983,P=0.012)有密切联系,和妊娠次数(χ~2=2.256,P=0.133)关系不大。结论出现先兆流产症状的孕妇其血清中E_2、P和β-HCG的水平普遍降低。所以孕妇血清3种激素的浓度可以提示黄体功能不全导致的先兆流产。
Objective To study the relationship between serum E_2, P, β-HCG and threatened abortion in pregnant women in early pregnancy. Methods A total of 160 pregnant women with symptoms of threatened abortion who were treated in our hospital from April 2013 to April 2015 were selected as the observation group and 300 pregnant women who were checked to be normal were selected as the control group. The levels of serum E_2, P and β-HCG in the two groups were compared, and the correlation between the decline of hormones and the clinical data was analyzed. Results There was no significant difference in age (t = 0.619, P = 0.536), gestational age (t = 0.108, P = 0.914), BMI (t = 0.452, P = 0.651) , P = 0.769). There was no significant difference in serum levels of progesterone, human chorionic gonadotrophin and estradiol in the two groups at 6w, 6-8w, 8-10w and 10-12w There are significant differences. And as can be seen from the data, with the gradual shift of gestational age, pregnant women serum progesterone, human chorionic gonadotropin and estradiol concentrations also showed a gradual rise; serum hormone levels in pregnant women and pregnant women age (χ ~ 2 = 9.151, P = 0.002) and gestational age (χ ~ 2 = 10.983, P = 0.012), which was not related to the number of pregnancy (χ ~ 2 = 2.256, P = 0.133). Conclusions The levels of E_2, P and β-HCG in serum of pregnant women with threatened abortion generally decrease. So pregnant women serum concentrations of 3 hormones can prompt the luteal insufficiency of threatened abortion.