论文部分内容阅读
目的评定单用金刚烷胺、金刚烷胺与复方丹参或丙炔苯丙胺合用对早期帕金森病 (PD)患者治疗的效果和安全性。方法采用多中心、开放式分组 ,单用金刚烷胺组 (金刚烷胺组 ) 3 5例 ,金刚烷胺 +复方丹参组 (复方丹参组 ) 3 4例 ,金刚烷胺 +丙炔苯丙胺 (丙炔苯丙胺 )组 2 9例。临床疗效采用改良Webster量表和帕金森病运动功能 (MDRSPD)量表 ,在治疗前及以后每 2个月进行 1次评定 ,期限为 1年 ,观察药物的临床疗效及副作用。同时在治疗前后取血查肝肾功能、血糖及血常规、尿常规。结果Webster量表和MDRSPD量表的临床有效率 ,单用金刚烷胺组分别为 42 9%和 3 7 1% ,复方丹参组分别为 3 4 2 %和 2 6 5 % ,丙炔苯丙胺组分别为 5 1 1%和 48 3 % ,经t检验差异无显著性。MDRSPD量表的临床显效率 ,金刚烷胺组为 2 8% ,复方丹参组为 11 8% ,丙炔苯丙胺组为 2 7 6%。复方丹参组与金刚烷胺组相比 ,差异无显著性 ;丙炔苯丙胺组与金刚烷胺组相比 ,差异有显著性。不良反应的发生率在以上 3组分别为 2 7 8%、8 8%和 3 1% ,但均较轻微 ,持续时间短 ,不影响治疗。结论 3组方案对早期PD患者均有一定的疗效 ,金刚烷胺与丙炔苯丙胺组联合应用显效率较高
Objective To evaluate the efficacy and safety of combining amantadine, amantadine and salvia miltiorrhizal or propylane in the treatment of patients with early Parkinson’s disease (PD). Methods A total of 34 patients underwent amantadine (amantadine), amantadine + 30 mg salvia miltiorrhiza compound (compound salvia miltiorrhiza), 30 patients received amantadine plus propargine Ethinyl amphetamine) group 29 cases. Clinical Efficacy The modified Webster scale and Parkinson’s disease motor function (MDRSPD) scale were used to evaluate the clinical efficacy and side effects of the drug once every two months before and after treatment for a period of one year. At the same time before and after treatment to check the liver and kidney function, blood glucose and blood, urine routine. Results The clinical efficacy of the Webster scale and the MDRSPD scale were 42 9% and 37 1% for the amantadine alone group and 34.2% and 25.5% for the compound salvia miltiorrhiza group, respectively 5 51% and 48 3%, no significant difference by t test. The clinical effective rate of the MDRSPD scale was 28% in the amantadine group, 118% in the compound salvia miltiorrhiza group and 276% in the propyne amphetamine group. Compared with the amantadine group, there was no significant difference in the compound Salvia miltiorrhiza group; there was significant difference between the propyne amphetamine group and the amantadine group. The incidence of adverse reactions in the above three groups were 27.8%, 88% and 31%, respectively, but were minor, short duration, does not affect the treatment. Conclusions The three groups have certain curative effect on patients with early PD, and the combination of amantadine and propyne is more effective