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目的:探讨非高密度脂蛋白胆固醇(non-HDL-C)和高密度脂蛋白胆固醇(HDL-C)比值与海勤官兵亚临床动脉粥样硬化(SA)的相关性及其临床意义。方法:回顾性分析陆军厦门特勤疗养中心2015年6月至2018年6月118例SA海勤官兵(SA组)的病例资料，按照颈动脉内中膜厚度(C-IMT)和斑块的发生情况分为增厚组(n n＝60例)和斑块组(n n＝58例)；以同期入院疗养且体检健康的海勤官兵60例为对照组。比较各组间常规体检参数包括临床资料参数如心血管健康行为因素评分、C-IMT和血糖，以及血脂参数如三酰甘油(TG)、总胆固醇(TC)、HDL-C、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、non-HDL-C/HDL-C、血浆致动脉硬化指数(AIP)。对C-IMT和AIP行相关性和多元线性回归分析；对颈动脉斑块发生情况行二元Logstic回归分析。n 结果:方差分析结果显示，对照组、增厚组、斑块组的TG、TC、LDL-C、non-HDL-C、AIP、non-HDL-C/HDL-C、C-IMT均依次显著升高，HDL-C、运动评分、健康饮食评分均依次显著降低(n P<0.05或n P<0.01)。相关性分析结果显示，non-HDL-C/HDL-C与C-IMT和AIP呈正相关(n P<0.05或n P<0.01)。回归分析结果显示，non-HDL-C/HDL-C均进入分别以C-IMT和AIP为因变量的回归模型(n P0.05)。n 结论:SA海勤官兵存在明显血脂代谢异常。non-HDL-C/HDL-C与C-IMT和AIP呈正相关性，是海勤官兵SA的危险因素，可作为评价海勤官兵SA的良好指标，应在海勤官兵血脂控制中重点关注。“,”Objective:To investigate the correlation and its clinical significance between the ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol (non-HDL-C/HDL-C) and subclinical arteriosclerosis (SA) in officers and seamen of naval special duty.Methods:A total of 118 officers and seamen of naval special duty with SA admitted to Xiamen Special Services Recuperation Center of the Army from June 2015 to June 2018 were selected as SA group. According to the carotid intima-media thickness (C-IMT) and plaque occurrence, they were divided into two subgroups: 60 cases in thickening group and 58 cases in plaque group. And another 60 officers and seamen of naval special duty admitted in the sanatorium in the same period for resting were selected into control group as they were healthy after examination. Routine physical examination recordings were compared among those groups, including general clinical data (cardiovascular health behavioral factors score, C-IMT, and blood glucose) and recordings on lipid [triglyceride (TG), total cholesterol (TC), HDL-C, low density lipoprotein cholesterol (LDL-C), non-HDL-C, non-HDL-C/HDL-C ratio, and atherogenic index of plasma (AIP)]. C-IMT and AIP were analyzed by correlation and multiple linear regression, and carotid plaque occurrence was analyzed by binary logistic regression.Results:①Among the control group, the thickening group, and the plaque group, variance analysis showed that TG, TC, LDL-C, non-HDL-C, AIP, non-HDL-C/HDL-C, C-IMT increased in turn significantly, while HDL-C, exercise score, and healthy diet score decreased in turn significantly (n P<0.05 orn P<0.01). ②Correlation analysis showed that there was a positive correlation of non-HDL-C/HDL-C with C-IMT and AIP, respectively (n P<0.01 orn P<0.05). ③Regression analysis showed that non-HDL-C/HDL-C entered the regression model with C-IMT and AIP as dependent variables (n P0.05).n Conclusion:There is obvious abnormal lipid metabolism in officers and seamen of naval special duty with SA. Non-HDL-C/HDL-C is positively correlated with C-IMT and AIP, which is a risk factor of officers and seamen of naval special duty with SA and can be used as a good index for evaluating officers and seamen of naval special duty with SA. Among the officers and seamen of naval special duty, the control of lipid should be focused on.